4-Bromo-2-chloro-pyridine is a useful synthetic intermediate. It is used to synthesize 3-[[4-(2-Methoxyphenyl)-2-pyridinyl]amino]-benzenemethanesulfonamide which is a potent CDK9 inhibitor in midline carcinoma therapy. It can also be used to prepare (pyrimidinylamino)benzamide derivatives that have anticancer activity as hedgehog signaling pathway inhibitor.
精确质量:190.91400
PSA:12.89000
LogP:2.49750
2-溴-4-氯吡啶(CAS:22918-01-0)物化性质
外观与性状:灰白色结晶
密度:1.7336 g/mL at 25 °C(lit.)
熔点:27ºC
沸点:70 °C / 3mmHg
闪点:225 °F
折射率:n20/D 1.5900(lit.)
2-溴-4-氯吡啶(CAS:22918-01-0)安全信息
危害声明:H302; H315; H318; H335
警示性声明:P261; P280; P305 + P351 + P338
海关编码:2933399090
WGK Germany:3
危险类别码:R22; R37/38; R41
安全说明:S26-S36
危险品标志:Xn
2-溴-4-氯吡啶(CAS:22918-01-0)用途
可用于有机合成。